When I reload my plugin using the "PluginChange" command, it removes my plugin from the list.
After reloading all plugins again I can tick it on again, but to get it to work, I have to reload it again, which also removes it from the list...
Anyone an idea what I am doing wrong?

Seems as you plugin have an error.. When a plugin errors on a reload, MsgPlus! will untick it from the list... Thereby it will not be loaded...
You might want to check your code through...
Is it in VB?... If yes, then I suggest you do not use "On Error Resume Next" or "On Error Goto xxxx" if you have used that code?....

Edit: Btw, welcome to the forum..

Thanks, and no, it isn't a code problem.
The old days (yesterday) when I had no problems reloading it, it just worked normal.