Try deleting with Unlocker. It kills all process associated with a file and also lets you delete a file on startup. Delete on Next Boot should do the trick for sure.
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RE: corrupt file
I had that problem on my external hard drive. What I did was run chkdsk /f/r <letter of drive> (example chkdsk /f/r C: ), and it made the file accessible.
This post was edited on 11-19-2006 at 03:52 PM by Reaper.