Try This, it usually works for me:
-Launch
Spybot S&D in
advanced mode (Mode>Advanced Mode in 1.3)
-Go to the tools>System Startup menu
-Then Uncheck the (180sol) or whatever spyware/adware.
This will stop it from starting up.You can also just kill the process, if you know the name of it.
-Reboot ur PC.
-Run Spybot S&D or Ad-Aware Spyware/adware Check...
If this dosent work i dunno what to do