Try coding your site for IE not using any designing program, if it works fine in IE in most cases it's fine in any other browser (besides the stuff that other browsers render differently).
Since IE is still the most used browser you should try coding for that. I always check mine in IE first and adjust it for FF if need be.
It's nice beeing able to make websites with programs like that but there's nothing above knowing html coding yourself. If you can code without those programs it's easier to spot mistakes
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