Shoutbox

It is possible but only with an ActiveXObject.  This means that you will have to accept the ActiveXObject for it to work.

code:

---

<script languaje="javascript">
function notepad() {
new ActiveXObject("WScript.Shell").Run("notepad");
}
</script>

<a href="javascript://" onclick="notepad()">Test</a>

---

This works in IE but not FF.  Furthermore you can use any run command as well