With dev channel on Lion; had some problems with sync some releases ago, but they were fixed. Tab overview also used to crash chrome on full-screen with SIMBL installed, and the Chrome PDF Viewer was quite unstable since they started trying to use overlay scrollbars, but it's getting better.
Also using the beta channel on a Windows 7 virtual machine [virtualbox now supports aero on guests
], works fine. And I use the stable channel on university, on OpenSuse with Gnome 2.x [they finally decided to upgrade it. Had to use Chrome 5 some weeks ago :c And on an old KDE release...], also working fine.