Shoutbox

I mean delete. But first make absolutely sure you don't need those programs! Of some I know 500% for sure you don't need them (like the office osa.exe), but for others I'm only 99% sure as I don't know what you do on your computer or what programs you have running/require... Read the manuals of the programs of which you're going to delete the stuff, test it out first, etc...

Also make first a backup of that HKLM\SOFTWARE\Microsoft\Windows\CurrentVersion\Run key and the other ones you're going to change (select the key and choose export in your registry editor)...